Author(s)

R. Miftakhov & D. Wingate

Abstract

Numerical simulation of electrochemical interaction between cholinergic and adrenergic neurones R. Miftakhov & D. Wingate Gastrointestinal Science Research Unit, The Royal London Hospital Medical College, London El 2AJ, ABSTRACT A mathematical model of cholinergic and adrenergic neurones has been developed, based on the electrophysiological data of the dynamics of nerve- pulse propagation along the geometrically non-uniform unmyelinated nerve axon and the pharmacokinetic mechanisms of electrochemical coupling in the cholinergic/adrenergic synapses. The model assumes that adrenoceptors, located at the axo-axonic piesynaptic junction, provide a presynaptic inhibition of an excitatory signal transfer via the cholinergic neurone. The model quantitatively describes: a) the processes of nerve-pulse propagation along the axons, b) the neurotransmitters release, c) diffusion of their fractions into the synaptic cleft, d) binding with receptors located on the postsynaptic membranes, a

Keywords