Author(s)

T.B. Martonen, D. Hwang, X. Guan, Y. Yang & J.S. Fleming

Abstract

This manuscript concerns a component of an international collaborative research program involving matters of aerosol therapy and nuclear medicine. Specifically, we shall address applications of supercomputer simulations of lung morphology to the medical arena Laboratory investigators use a variety of techniques (PET, the planar gamma camera, and SPECT) to define the geometry of the human lung via images and measure the distributions of aerosolized drugs or diagnostic particles and gases. The techniques have inherent limitations regarding their respective capabilities of spatial discrimination. The fundamental problem is: how can particle deposition and/or gas uptake be identified on a localized, airway-by-airway basis? If the resolution of such images c

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