Author(s)

W. Schreiner, F. Neumann, M. Neumann & R. Karch

Abstract

The procedure of Constrained Constructive Optimization (CCO) generates a binary branching model of vascular segments, represented as straight cylindrical tubes through which resistance to blood flow follows Poiseuille's Law. While several constraints regarding pressures, flows and branching radii are fulfilled throughout the optimization process, the branching structure is generated so as to convey blood to each site of a perfusion area, where it is delivered into the microcirculation. As every real arterial tree CCO-models also comprise a mixture of "conveying" and "delivering" elements of funct

Keywords