Author(s)

C.A. Lodi, M. Ursine, A.T. Minassian & L. Beydon

Abstract

A Mathematical Model of Intracranial Pressure and Cerebral Hemodynamics Response to COi changes C.A. Lodi", M. Ursine", A. T. Minassian\ L. Beydon* "Department of Electronics, Computer Science and Systems, University of Bologna, Viale Risorgimento 2, 40136 Bologna, Italy E-Mail: calodi@deis.unibo.it ^Department ofAnesthesiology, Service of Anesthesiology and Intensive Care, Henri Mondor Hospital, 51 Avenue du M"* de Lattre-de-Tassigny, 94010 Creteil, France Abstract Alterations in blood CO] tension (paco) are frequently used in neurosurgical Intensive Care Units to manage patients with severe brain diseases and to test the status of mechanisms regulating cerebral blood flow. In this work, the complex relationships between Pacc>2> cerebral blood volume, cerebral blood flow and intracranial pressure (ICP) are investigated by means of an original mathematical model. The model incorporates the intracranial compliance, the cerebrospinal fluid production and reabsorption processes, the

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