Author(s)

X.Y. Xu, M.W. Collins & T.M. Griffith

Abstract

Numerical modelling of flow-dependent dilatation in a carotid artery X.Y. Xu", M.W. Collins" & T.M. GriEth^ "Thermo- Fluids Engineering Research Centre, City University, London ECl V OHB, UK ^Department of Diagnostic Radiology, University of ABSTRACT To investigate the immediate cause and effect of EDRF release, namely the wall shear stress variation and wall mechanical characteristics respectively, numerical predictions of flow and wall behaviour in distensible carotid ar- teries have been conducted. In this paper, the first phase of this study is presented. Using the ultra high-precision in vivo ultrasound data, three- dimensional flow in an intact porcine common carotid artery with ipsilateral infusion of 0.1//M bradykinin has been calculated. The numerical prediction scheme utilised the transient gridding technique to accommodate the mov- ing vessel wall. Full details of wall shear stress history have been obtained. The combination of numerical predictions and in vivo measure

Keywords