Author(s)

P. Krumbiegel, 0. Herbarth, M. Richter & I. Koschny

Abstract

A stable isotope based human exposure test to study SC>2 load effects P. Krumbiegel", 0. Herbarth", M. Richter", I. Koschny"^ ^Department of Human Exposure Research and Epidemiology, Centre for Environmental Research, D-04301 Leipzig, Germany D-04579 Espenhain, Germany Abstract Over three years, air pollution has been controlled in a Saxon industrial region using 862 as an indicator component. S02 is known to come from large-scale lignite combustion used in power stations there. At the same time, children of two kindergartens near the power stations who belong to a typical risk group, were tested two times a year. i. e., in March and in September. For this, a stable isotope based function test was developed and used to study actual activities of the hepatic monooxygenases: A certain amount of the stable isotope diagnostic agent [I^Njmethacetin was administered orally. Over 9 hours, the total urinary amount of ^N characterizing the sum of eliminated metha

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