Author(s)

D. Miklavčič, G. Pucihar, L. M. Mir, M. Puc, K. Flisar, A. Maček Lebar, M. Mali, G. Serša, S. Kranjc, M. Čemažar, M. Petkovšek & J. Nastran

Abstract

Increased pulse repetition frequency for effective and less painful electrochemotherapy D. ~iklavCiC', G. Pucihar', L. M. Mir2, M. Pucl, K. Flisarl, A. MaCek ~ebar', M. Mali1, G. Ser5a3, S. Kranjc3, M. Cemaiar", M. ~etkov~ek' & J. Nastran' l~aculty of Electrical Engineering, University of Ljubljana, Slovenia ~ U M R 8532 CNRS: Institute Gustave-Roussy, France 3~e~artment of tumor biology, Institut of Oncology, Slovenia Abstract Electrochemotherapy is a technique where electric pulses in combination with chemotherapeutic agents are applied to tumor cells. In general, patients fmd electrochemotherapy tolerable, in spite of unpleasant sensations associated with contraction of muscles located in the vicinity of the electrodes. Usually a train of eight electric pulses with repetition frequency of 1 Hz is applied to the tumors and each pulse in the train provokes muscle contraction. The use of pulses with repetition frequency higher than the frequency of tetanic contraction would represent reduced n

Keywords