Author(s)

B. Music, T. Jarm, F. Jager & D. Miklavčič

Abstract

Algorithm for synchronization of electroporation pulse delivery with electrocardiogram B. Music1, T. ~arrn', F. ~ a ~ e r ~ & D. Miklav~i~' I University of Ljubljana, Faculty of Electrical Engineering, Slovenia. 2 University of Ljubljana, Faculty of Computer and Information Science, Slovenia. Abstract Electrochemotherapy is a local treatment of tumors in which high voltage electric pulses are used for permeabilization of cell membrane (electroporation) thus enabling increased entry of chemotherapeutic molecules into tumor cells. Application of electroporation pulses to tumors located close to the heart muscle could lead to fibrillation of the heart if the pulses are delivered during the vulnerable period of the heart or if the pulses coincide with heart arrhythmias due to lowered threshold for fibrillation. We present an algorithm based on the analysis of a single-lead electrocardiogram. The algorithm enables safe use of electrochemotherapy by allowing the electroporation pulses to be delivere

Keywords