Author(s)

X.L. Soldat and X.D. Thrall

Abstract

Design and evaluation of a breath analysis system for occupational exposure assessment K. L. Soldat and K. D. Thrall Pacific Northwest National Laboratory, United States of America Abstract Exposure assessment is an integral part of industrial hygiene and occupational health. To ensure the health and safety of workers, integrated industrial hygiene methodologies often include biological monitoring strategies. Exhaled breath is an ideal matrix for measuring volatile biomarkers, particularly since the non- invasive collection of breath may improve volunteer participation. A real-time, field-portable system was developed to analyze undiluted exhaled air from experimental animals and humans. The system combines 1) an ion-trap mass spectrometer capable of atmospheric sampling; 2) a breath interface for continual analysis of the exhaled breath stream; 3) chemical dosimeters that are analyzed in the field/workplace; and 4) physiologically based pharmacokinetic (PBPK) models to es

Keywords